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Symptom: DEPRESSIONCause: Drugs
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Description:
Various drugs cause depression as an adverse effect. Among the more common are barbiturates; chemotherapeutic drugs, such as asparaginase; anticonvulsants, such as diazepam; and antiarrhythmics, such as disopyramide. Other depression-inducing drugs include centrally acting antihypertensives, such as reserpine (common in high dosages), methyldopa, and clonidine; beta-adrenergic blockers, such as propranolol; levodopa; indomethacin; cycloserine; corticosteroids; and hormonal contraceptives



Symptom: DYSPEPSIACause: Drugs
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Description:
Nonsteroidal anti-inflammatory drugs, especially aspirin, commonly cause dyspepsia. Diuretics, antibiotics, antihypertensives, corticosteroids, and many other drugs can cause dyspepsia, depending on the patient-s tolerance of the dosage


Symptom: VERTIGOCause: Drugs and alcohol
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Description:
High or toxic doses of certain drugs or alcohol may produce vertigo. These drugs include salicylates, aminoglycosides, antibiotics, quinine, and hormonal contraceptives


Symptom: IMPOTENCECause: Alcohol and drugs
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Description:
Alcoholism and drug abuse are associated with impotence, as are many prescription drugs, especially antihypertensives. (See drugs that may cause impotence, page 364.)


Symptom: OLIGURIACause: Drugs
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Description:
Oliguria may result from drugs that cause decreased renal perfusion (diuretics), nephrotoxicity (most notably, aminoglycosides and chemotherapeutic drugs), urine retention (adrenergics and anticholinergics), or urinary obstruction associated with precipitation of urinary crystals (sulfonamides and acyclovir)



Symptom: MIOSISCause: Drugs
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Description:
Such topical drugs as acetylcholine, carbachol, demecarium bromide, echothiophate iodide, and pilocarpine are used to treat eye disorders specifically for their miotic effect. Such systemic drugs as barbiturates, cholinergics, anticholinesterases, clonidine (overdose), guanethidine monosulfate, opiates, and reserpine also cause miosis, as does deep anesthesia


Symptom: HEADACHECause: Drugs
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Description:
Many drugs can cause headaches. For example, indomethacin produces headaches?usually in the morning?in many patients. Vasodilators and drugs with a vasodilating effect, such as nitrates, typically cause a throbbing headache. Headaches may also follow withdrawal from vasopressors, such as caffeine, ergotamine, and sympathomimetics


Symptom: GYNECOMASTIACause: Drugs
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Description:
When gynecomastia is an effect of drugs, it-s typically painful and unilateral. Estrogens used to treat prostate cancer, including diethylstilbestrol, estramustine, and chlorotrianisene, directly affect the estrogen-androgen ratio. drugs that have an estrogen-like effect, such as cardiac glycosides and human chorionic gonadotropin, may do the same. Regular use of alcohol, marijuana, or heroin reduces plasma testosterone levels, causing gynecomastia. Other drugs?such as flutamide, cyproterone, spironolactone, cimetidine, and ketoconazole ?produce this sign by interfering with androgen production or action. Some common drugs, including phenothiazines, tricyclic antidepressants, and antihypertensives, produce gynecomastia in an unknown way



Symptom: PERICARDIAL FRICTION RUBCause: Drugs
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Description:
Procainamide and chemotherapeutic drugs can cause pericarditis


Symptom: JAW PAINCause: Drugs
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Description:
Some drugs, such as phenothiazines, affect the extrapyramidal tract, causing dyskinesias; others cause tetany of the jaw secondary to hypocalcemia
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